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Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei. Greater cigarette quantity/exposure was related to smaller volumes in regions that also showed greater age-related volume loss in smokers.
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The ads will commence Nov. 26. Full-page newspaper ads will run in major U.S. metropolitan areas, and 30- to 45-second spot ads will be shown on the ABC, CBS and NBC television networks. In North Carolina, the newspaper ads will be published only in Charlotte. The ads are projected to cost several millions of dollars for each manufacturer. R.J. Reynolds Tobacco Co. said Tuesday that it could cost $20 million to comply. Reynolds spokesman David Howard said Reynolds remains the entity obligated to comply with the court order even though it is now the U.S. subsidiary of British American Tobacco PLC.