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Volume 177 , 1 August 2017, Pages 268-276 Reward-related frontostriatal activity and smoking behavior among adolescents in treatment for smoking cessation Author links open overlay panel Kathleen A.Garrisona One of the first longitudinal fMRI studies of smoking cessation treatment in adolescents. Adolescents show increased non-drug reward-related brain activity pre- to post-treatment. Increases in reward-related brain activity were associated with smoking abstinence. Tobacco use is often initiated during adolescence and continued into adulthood despite desires to quit. A better understanding of the neural correlates of abstinence from smoking in adolescents may inform more effective smoking cessation interventions. Neural reward systems are implicated in tobacco use disorder, and adolescent smokers have shown reduced reward-related ventral striatal activation related to increased smoking. The current study evaluated nondrug reward anticipation in adolescent smokers using a monetary incentive delay task in fMRI pre- and post- smoking cessation treatment (n = 14). This study tested how changes in neural responses to reward anticipation pre- to post-treatment were related to reduced smoking. An exploratory analysis in a larger sample of adolescents with only pre-treatment fMRI (n = 28) evaluated how neural responses to reward anticipation were related to behavioral inhibition and behavioral activation scales. Adolescent smokers showed pre- to post-treatment increases in reward anticipation-related activity in the bilateral nucleus accumbens and insula, and medial prefrontal cortex, and greater increases in reward anticipation-related activity were correlated with larger percent days of smoking abstinence during treatment. These findings suggest that reduced smoking during smoking cessation treatment is associated with a “recovery of function” in frontostriatal responses to nondrug reward anticipation in adolescent smokers, although comparison with a developmental control group of adolescent nonsmokers is warranted.
Lucas Herscovici, a global marketing executive at the beer giant, said the consolidation was designed to “reduce complexity.” Usually, that’s code for cost savings, but Mr. Herscovici insisted that wasn’t the motivation. Still, he admitted, “In every pitch of this nature when you’re involving over 50 countries [with] spends in the hundreds of millions of dollars, and when there’s competition across agencies, obviously savings are achieved.” Winning shops should feel good about adding business at a time when most holding companies are reporting subpar growth. They shouldn’t bank on major profits from programmatic fees. The company already handles programmatic buying in-house and plans to expand the model globally, Mr. Herscovici said. WPP reportedly isn’t ready to give up its 24.7% stake in Japanese ad agency Asatsu-DK for the ¥152 billion ($1.35 billion) price private-equity firm Bain Capital has offered for the company. People close to WPP said the tender “severely undervalues” the Japanese firm. [ Financial Times ] EMarketer has lowered its 2017 ad revenue forecast for Snapchat. The research firm now thinks Snapchat will generate $774.1 million in ad revenue world-wide this year, down from its March prediction of $900 million. [ eMarketer ] Those aforementioned Russian entities reportedly used Facebook’s Custom Audiences retargeting tool to identify voters susceptible to being influenced and repeatedly send them ads.